Giardia

16Giardia is a relatively simple eukaryotic microbe, causing acute and chronic diarrhea which has been used as a model to understand complex biological processes occurring in eukaryotic cells. Further, due to its parasitic lifestyle, Giardia is an excellent system for the study of the mechanisms of adaptation and cell differentiation from the perspectives of molecular and cell biology.This book presents a comprehensive review of the current state of knowledge regarding all aspects of Giardia s biology, including epidemiology, cell and molecular biology, genetics, pathogenesis, diagnostics, and clinical treatment. It was written by internationally renowned authors, the leading researchers in the field including several chapters with techniques and resources available for the study of this microorganism. Questions that need to be addressed to fully understand the molecular mechanisms of the parasite as well as the cause of its pathology are presented. Furthermore, Giardia s biology i16s compared with that of other parasites in relation to their complexity.This volume is an indispensable resource for researchers working with this parasite. It is a must for libraries and the bookshelves of everyone interested in the biology of parasites and early-branching eukaryotes.04Preface and IntroductionSection I: Taxonomy and Epidemiology of Giardia1- Taxonomy of Giardia species2- Epidemiology of Giardia lamblia3- Waterborne and Environmentally-borne Giardiasis4- Giardia in Pets, Farm animals and zoonotic potentialSection II: Molecular Biology of Giardia5- Genomics of Giardia lamblia6- Proteomics and Glycomics of Giardia lamblia7- Lipidomics of Giardia lamblia8- General Giardia MetabolismSection III: Cellular Biology of Giardia9- Ultrastructure of Giardia during growth and differentiation10- Cell cycle regulation and cell division in Giardia11- The Giardia Mitosomes12- Signal transduction pathways in Giardia13- Transcription and Recombination in Giardia14- Intracellular protein trafficking15- The RNAi Pathway in Giardia 16- Antigenic Variation in Giardia17- Translation and RNA processing in GiardiaSection IV: Pathology, treatment and diagnostics of Giardia and the host immune response18- Interaction of Giardia with host cells19- The04 Giardia cytoskeleton20- Pathology and clinical manifestations of Giardiasis21- Immunology of Giardiasis22- Treatment of Giardiasis and Drug Resistance23- Giardia Metabolism and Drug Development24- Vaccination against Giardia25- Diagnostics of Giardia infectionsSection V: Methods for Giardia ResearchMethods for Giardia culture and differentiation in vitroMethods for Giardia synchronizationMethods for Giardia transfection and gene expressionCurrent tools to study Giardia in the lab